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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often characterized by their focus on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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Pragmatic is a software company that offers a broad range of casino games available on online gambling platforms. Its iGaming solutions are used by the most reputable operators as well as casinos that are located in the land. The company provides front-end tools for design, analysis, promotions, marketing and payment systems, as well as security, customer service, and bug reporting. Additionally, the company provides its players a safe and secure environment with high-quality graphics as well as gameplay.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from different geographical regions. This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity and also helps to reduce bias in the results. However excessive heterogeneity could result in problems with the design of the trial.
Pragmatic Play is also a major player in the live casino market, providing an array of table games that are classic such as Blackjack and Roulette in various versions. The company's live studios in Romania and Malta provide a genuine gambling experience for players, as well as a wide range of virtual betting options. The company also has created several interactive game shows to make gambling online enjoyable. Some of these shows feature live hosts, whereas others are hosted by famous personalities from the industry.
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Pragmatic Play is a new player in the online casino market however, it has earned a name by offering mobile-friendly slots. Their games are optimized for mobile devices, and run using HTML5 technology. They're also endorsed by trusted gaming authorities to ensure transparency and fairness. This is a positive sign for players, as it implies that the games are tested and verified to ensure that the results of every round are fair and impartial.
Pragmatic Play offers not only mobile-friendly slot machines but also live casino and table games. Pragmatic Play is licensed and regulated by several authorities which include the Malta Gaming Authority and UK Gambling Commission. The games are protected by high-end encryption and the security team is ready to assist players with any issues they may have.
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Legality
Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software is accessible on mobile devices and in multiple languages. Despite its relatively young age it has established itself as a top casino gaming platform. Wolves is one of the latest games, a 5-reel slot machine with a healthy RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.
Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually ordered by policymakers and practitioners to inform their decisions. They also provide a useful method to determine the causality between the intervention and its effects. They should, however, not be used to replace explanatory studies.
The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a practical trial which includes the recruitment process, the design and implementation of the intervention, as well as monitoring.
There is an encouraging increase in the number of pragmatic trials published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to note, however, that the majority of studies were conducted in primary-care settings.